Topical application of a beta-blocker to the eye reduces intra-ocular pressure effectively in primary open-angle glaucoma, probably by reducing the rate of production of aqueous humour. Administration by mouth also reduces intra-ocular pressure but this route is not used since side-effects may be troublesome.
CAUTIONS, CONTRA-INDICATIONS AND SIDE-EFFECTS (See BNF).
INTERACTIONS, Since systemic absorption may follow topical application the possibility of interactions, in particular, with drugs such as verapamil should be borne in mind. See also BNF Appendix 1 (beta-blockers).