Formulary Chapter 4: Central nervous system - Full Chapter
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04.02.01 |
Antipsychotic Drugs |
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04.02.01 |
Second-Generation Antipsychotic Drugs |
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Amisulpride
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Restricted
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- Amisulpride Tablets
- Amisulpride Oral Solution
Restricted to Psychiatry specialist recommendation only
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DSU: Clozapine and other antipsychotics: monitoring blood concentrations for toxicity (August 2020)
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Aripiprazole
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Restricted
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- Aripiprazole Tablets
- Aripirazole Orodispersible Tablets
Aripiprazole Oral Solution (note high cost, only use if the tablets or orodispersible tablets aren't appropriate) Restricted for Consultant Psychiatrist recommendation only.
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DSU: Clozapine and other antipsychotics: monitoring blood concentrations for toxicity (August 2020)
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Clozapine (Clozaril®)
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Restricted
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Restricted for Consultant Psychiatrist use only.
- Registration needed for all patients on this treatment.
- Service managed by BDCT. Contact 01274 363230 (Linfield Mount Pharmacy) in normal working hours for information or assistance.
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DSU: Clozapine and other antipsychotics: monitoring blood concentrations for toxicity (August 2020)
DSU: Clozapine: reminder of potentially fatal risk of intestinal obstruction, faecal impaction, and paralytic ileus (October 2017)
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Lurasidone
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Restricted
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Restricted for Psychiatry specialist recommendation only.
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Olanzapine (Zyprexa®, Zalasta®)
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Restricted
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Olanzapine tablets
Olanzapine injection
Olanzapine Orodispersible Tablets
Reserved for use in patients who cannot swallow tablets only
Restricted for Psychiatry specialist recommendation only
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DSU: Clozapine and other antipsychotics: monitoring blood concentrations for toxicity (August 2020)
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Quetiapine (Seroquel®, Sondate XL)
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Restricted
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- Quetiapine Tablets
- Quetiapine MR Tablets
Reserved for Psychiatry specialist recommendation only Note: Sondate XL® is the preferred brand of Quetiapine XL in primary care.
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DSU: Clozapine and other antipsychotics: monitoring blood concentrations for toxicity (August 2020)
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Risperidone (Risperdal®)
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Formulary
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- Risperidone Tablets
- Risperidone Liquid
Restricted to patients who are unable to swallow tablets.
- Risperidone Orodispersible Tablets
Reserved for patients who do not tolerate risperidone liquid, do to high cost.
Restricted to Psychiatry specialist recommendation only
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DSU: Clozapine and other antipsychotics: monitoring blood concentrations for toxicity (August 2020)
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Non Formulary Items |
Paliperidone tablets (Invega®)

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Non Formulary
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Paliperidone modified release tablets are not routinely commissioned based on significant cost without additional clinical benefits in comparison with risperidone tablets. |
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Key |
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Cytotoxic Drug
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Controlled Drug
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High Cost Medicine
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Cancer Drugs Fund
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NHS England |
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Homecare |
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CCG |
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Traffic Light Status Information
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Description |

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Green - Drugs suitable for generalised use in accordance with position summary.
Inform primary care of need to prescribe using a TTO chart if in patient or Treatment Advice Note (TAN) if Outpatient.
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Amber - these drugs require specialist initiation or recommendation |

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Amber Share Care - Drugs suitable for generalist use, in accordance with position summary, normally following specialist initiation and stabilisation. Ongoing division of responsibility for drug and disease monitoring between specialist and GP by a Shared Care Guideline (SCG). If no SCG in place status reverts to red. |

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Red - Drugs for specialist use only, in accordance with position summary. GP’s should not be asked to prescribe these products. |

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Red ULM - Unlicensed medicines for specialist use only, in accordance with position summary. GP’s should not be asked to prescribe these products. |

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Grey drugs - No formal commissioning position. Check appropriate CCG /NHSE commissioning list or contact CCG/NHSE Medicines Management team for advice. Fill in individual funding request for appropriate CCG/NHSE. This will need to be signed by the Chief Pharmacist and a copy of the relevant DTC submission attached. |

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Black - Drugs not routinely commissioned so should not usually be prescribed |
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